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KMID : 0614620160670050267
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Korean Journal of Gastroenterology
2016 Volume.67 No. 5 p.267 ~ p.271
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Concomitant Drug Reaction with Eosinophilia and Systemic Symptom Syndrome from Ethambutol and Autoimmune Hepatitis from Isoniazid
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Choi Joon-Hyuk
Heo Nae-Yun
Park Seung-Ha
Park Chan-Sun
Jo Kyeong-Min
Kim Woo-Gyeong
Nam Kyung-Han
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Abstract
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Anti-tuberculosis drugs can produce levels of hepatotoxicity ranging from mild elevation of aminotransferase to severe acute hepatitis. A few cases of drug-induced autoimmune hepatitis or the drug reaction with eosinophilia and systemic symptom (DRESS) syndrome by anti-tuberculosis medications have been reported. However, concomitant occurrence of these two disorders has not been reported. Here, we present a case of severe acute hepatitis with DRESS syndrome and autoimmune hepatitis resulting from primary standard anti-tuberculosis drugs. Both conditions were successfully treated with a systemic steroid regimen.
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KEYWORD
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Drug hypersensitivity syndrome, Hepatitis, autoimmune, Antitubercular agents
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